Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic anhydride
REAGENT Trifluoroacetic anhydride
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid puriss. p.a., for HPLC, 99.0 (GC), 76-05-1, MFCD00004169
Trifluoroacetic acid puriss. p.a., for HPLC, 99.0 (GC)
Medchemexpress LLC Cn2 toxin TFA (β-mammal toxin Cn2 TFA) | 96.6% | 7588.60 (free base) | 500 UG
Cn2 toxin TFA (β-Mammal toxin Cn2 TFA) is a single-chain β-scorpion neurotoxic peptide. As the main toxin found in scorpion venom, Cn2 toxin (TFA) specifically targets mammalian voltage-gated sodium channels (VGSC) Nav1.6. It is intended for research use only.
- Single-chain β-scorpion neurotoxic peptide
- Main toxin found in scorpion venom
- Specifically targets mammalian voltage-gated sodium channels (VGSC) Nav1.6
- White to off-white solid appearance
Medchemexpress LLC Ncgc00138783 TFA | 00-00-0 | 99.4% | 617.62 g·mol⁻¹ | C28H27F4N7O3S | 5 MG
NCGC00138783 TFA is a small-molecule inhibitor that selectively targets the CD47/SIRPα immune checkpoint, blocking the CD47-SIRPα interaction with reported in vitro activity (IC50 ≈ 50 μM). Supplied as the trifluoroacetic acid (TFA) salt for research applications.
- Selective inhibitor of the CD47/SIRPα immune checkpoint.
- Reported IC50 approximately 50 μM in biochemical assays.
- Supplied as the trifluoroacetic acid (TFA) salt.
- High purity (99.4%).
- Molecular weight 617.62 g·mol⁻¹.
- Store at 4 °C; protect from moisture and light.
Medchemexpress LLC Dendrotoxin K TFA | 99.5% | 6559.66 (free base) | 1 MG
Dendrotoxin K TFA is a Kv1.1 channel blocker. It determines glutamate release in CA3 neurons in a time-dependent manner through the control of the presynaptic spike waveform.
- Kv1.1 channel blocker
- Determines glutamate release in CA3 neurons
- Controls presynaptic spike waveform
Medchemexpress LLC Hth-01-091 Tfa | 2000209-42-5 | 98.64% | 499.43 | 1 MG
HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor, with an IC50 of 10.5 nM. It also inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK, and CLK2. This compound can be used for breast cancer research.
- Potent and selective MELK inhibitor.
- Inhibits multiple kinases including PIM1/2/3, RIPK2, DYRK3, smMLCK, and CLK2.
- Suitable for breast cancer research.
Apexbio Technology LLC CTOP TFA 1mg
CTOP TFA is a small-molecule antagonist targeting the -opioid receptor (MOR) It is designed to selectively inhibit MOR thereby regulating opioid receptor-mediated neural signaling pathways CTOP TFA exerts its biological activity primarily through specific interaction with and inhibition of MOR in the central nervous system Based on these pharmacological properties CTOP TFA holds research potential in investigating pain perception analgesia tolerance dependence neurotransmitter release stress responses and emotional regulation
Medchemexpress LLC Survodutide TFA (BI 456906 TFA) | 99.4% | 4231.62 (free base) | 5 MG
Survodutide TFA (BI 456906 TFA) | 99.4% | 4231.62 (free base) | 5 MG
Medchemexpress LLC T-Boc-Met-Asp-Gly-Cys-Glu-Leu | 99.2% | 880.90 | 1 MG
Box5 TFA is a potent Wnt5a antagonist. It inhibits Wnt5a signaling and Wnt5a-mediated Ca2+ release, and also inhibits cell migration. It has the potential for the research of melanoma.
- In vitro: decreases the expression of rWnt5a (0.1 μg/mL) stimulated p-MARCKS in A2058 cells.
Medchemexpress LLC WDR5-IN-4 TFA | 2749300-35-2 | 98.0% | 612.40 | 1 ML
WDR5-IN-4 TFA (Compound C6) is an inhibitor of the WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5), with a Kd of 0.1 nM. It displaces WDR5 from chromatin and decreases the expression of associated genes, leading to translational inhibition and nucleolar stress. This compound also exhibits anti-cancer activity.
- Inhibits the proliferation of MLL1-rearranged cancer cells MV4:11 and K562 cells with GI50s of 3.20 μM and 25.4 μM respectively, when treated with 0-50 μM for 3 days.
- Arrests the cell cycle of MV4:11 at the sub-G1 phase and induces apoptosis in MV4:11 when treated with 2 μM for 6 days.
- Promotes Hox genes in hindbrains of Rnf220+/- mice at late embryonic stages with an intrauterine injection of 100 μg (single dose).
Medchemexpress LLC OS-2966 10mg | 10mg
OS-2966 is a humanized antibody expressed in CHO cells targeting Integrin b1/ITGB1/CD29 OS-2966 carries a huIgG1 type heavy chain and a hu type light chain with a predicted molecular weight (MW) of 145 5 kDa The isotype control for OS-2966 can be referenced as Human IgG1 kappa Isotype Control (HY-P99001)