Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Astressin 2B TFA | 99.5% | 4041.69 (free base) | 5 MG
Astressin 2B TFA | 99.5% | 4041.69 (free base) | 5 MG
Strem, An Ascensus Company CAS# 76-05-1. 100g. Trifluoroacetic acid, 99%. MFCD00004169
CAS# 76-05-1. 100g. Trifluoroacetic acid, 99%. MFCD00004169. Molecular Weight: 114.02. Molecular Formula: CF3COOH. Color/form: colorless liq. Strem# 09-7160. http://www.strem.com/catalog/v/09-7160/
Medchemexpress LLC Sar441255 TFA | 99.93% | 4866.56 (free base) | 5 MG
SAR441255 TFA is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. It displays high potency with balanced activation of all three target receptors and shows positive acute glucoregulatory effects in diabetic obese monkeys. This product is for research use only.
- Potent unimolecular peptide
- GLP-1/GIP/GCG receptor triagonist
- Displays high potency
- Balanced activation of target receptors
- Shows positive acute glucoregulatory effects
- For research use only
Medchemexpress LLC NLS-StAx-h TFA | 98.9% | 3559.28 | 1 MG
NLS-StAx-h TFA is a selective, cell permeable, stapled peptide that inhibits Wnt signaling, with an IC50 of 1.4 μM. It effectively inhibits interactions between β-catenin and transcription factors and demonstrates anti-proliferative effects on cancer cells, including SW-480 and DLD-1 colorectal cancer cells.
- Selective, cell permeable, stapled peptide
- Inhibits Wnt signaling with an IC50 of 1.4 μM
- Efficiently inhibits β-catenin-transcription factor interactions
- Shows anti-proliferation of cancer cells
- Inhibits proliferation of colorectal cancer cells (SW-480 and DLD-1 cells) by more than 80% at 10 μM
- Inhibits migration of DLD-1 colorectal cancer cells in a dose-dependent manner
Medchemexpress LLC AH-D peptide TFA | 98.8% | 3283.75 | 5 MG
AH-D peptide TFA is an antiviral peptide that selectively disrupts membrane structures within the size range of exosomes, inducing T-EXO depletion and enhancing cancer immunotherapy.
- Antiviral peptide
- Disrupts membrane structures within exosome size range
- Induces T-EXO depletion
- Enhances cancer immunotherapy
- Solid, white to off-white appearance
- Store sealed, away from moisture
- Powder storage at -80°C for 2 years, -20°C for 1 year
- In solvent storage at -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC GpTx-1 TFA | 1661050-12-9 | 99.6% | 4073.82 | 100 UG
GpTx-1 TFA is a peptide-based NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. It demonstrates potent inhibitory activity against the NaV1.7 channel with an IC50 value of 10 nM. This compound also exhibits excellent selectivity for NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM).
- Potent inhibitory activity against NaV1.7 channel with an IC50 value of 10 nM.
- Selective for NaV1.4 (IC50 = 0.301 μM).
- Selective for NaV1.5 (IC50 = 4.20 μM).
- IC50 for NaV1.3 is 0.0203 μM.
- IC50 for NaV1.8 is 12.2 μM.
Medchemexpress LLC Cef20 (Tfa) | 99.3% | 1057.19 | 25 MG
CEF20 TFA is an HLA-A*0201-restricted epitope from cytomegalovirus pp65 (495-503).
- High purity of 99.31%
- Molecular weight of 1057.19
- Solid appearance
- White to off-white color
- Sequence: Asn-Leu-Val-Pro-Met-Val-Ala-Thr-Val (NLVPMVATV)
- Soluble in DMSO
- Store in sealed container, away from moisture
- Powder storage: -80°C for 2 years, -20°C for 1 year
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
Apexbio Technology LLC SCH772984 TFA 942183-80-4 (free base) 5mg
SCH772984 TFA is a small-molecule inhibitor targeting extracellular signal-regulated kinase 1/2 (ERK1/2) It is designed to inhibit ERK catalytic activity thereby blocking phosphorylation of downstream substrates and regulating the RAS-RAF-MEK-ERK signaling pathway SCH772984 TFA exerts its biological activity primarily through direct interaction with ERK1/2 acting as an ATP-competitive inhibitor Based on these pharmacological properties SCH772984 TFA holds research potential in studies examining ERK signaling s role in oncogenic pathway activation tumor cell growth survival mechanisms and resistance phenomena in various cancer models
Medchemexpress LLC CPP12 (TFA) | 98.7% | 1700.55 | 5 MG
CPP12 TFA is a small, amphiphilic, cyclic cell-penetrating peptide (CPP) in salt form. It binds directly to plasma membrane phospholipids, enters mammalian cells via endocytosis, and is then efficiently released from endosomes. This peptide can be used for intracellular delivery of drugs and chemical probes.
- Small, amphiphilic, cyclic cell-penetrating peptide
- Binds directly to plasma membrane phospholipids
- Enters mammalian cells via endocytosis
- Efficiently released from endosomes
- Used for intracellular delivery of drugs and chemical probes
Medchemexpress LLC Cys-PKHB1 TFA | 1487.88 | 10MG
Cys-PKHB1 TFA is a peptide conjugated to PKHB1, functioning as a CD47 agonist peptide and a thrombospondin-1 peptide mimic with antitumor effects. It induces mitochondrial alterations, reactive oxygen species generation, and intracellular calcium accumulation, leading to calcium-dependent cell death in breast cancer cells. This compound also activates the immune system in breast cancer cells via immunogenic cell death.
- Conjugated peptide acting as a CD47 agonist
- Thrombospondin-1 peptide mimic
- Exhibits antitumor effects
- Induces mitochondrial alterations
- Promotes reactive oxygen species (ROS) generation
- Causes intracellular calcium (Ca+) accumulation
- Leads to calcium-dependent cell death in breast cancer cells
- Activates the immune system through immunogenic cell death
Medchemexpress LLC D2A21 TFA | 95.6% | 2775.42 | 5 MG
D2A21 TFA is an antimicrobial peptide with significant antimicrobial activity against Pseudomonas and a bactericidal effect on burn scabs. It also exhibits antitumor activity and can be used in prostate cancer research.
- Antimicrobial peptide with significant antimicrobial activity against Pseudomonas
- Bactericidal effect on burn scabs
- Has antitumor activity
- Can be used in prostate cancer research
Medchemexpress LLC L2P4 (TFA) | 98.3% | 1961.83 (free base) | 25 MG
L2P4 TFA is a peptide-based, EBNA1 targeting fluorescent probe that inhibits EBNA1 homodimer formation and selectively inhibits EBV+ tumor growth. It exhibits cytotoxicity in EBV-positive C666-1 cells with an LC50 of 46.4 μM.
- Peptide-based fluorescent probe
- Targets EBNA1
- Inhibits EBNA1 homodimer formation
- Selectively inhibits EBV+ tumor growth
- Exhibits cytotoxicity in EBV-positive C666-1 cells with an LC50 of 46.4 μM
- Relevant to peptide-drug conjugates (PDCs) and EBV research
- Related to antibody-drug conjugate/ADC and anti-infection pathways
Medchemexpress LLC GSNKSKPK-NH2 TFA | 99.91% | 843.97 (free base) | 1 MG
GSNKSKPK-NH2 TFA is a model peptide based on a c-Src N-terminal peptide that can be used as an NMT substrate.
- Model peptide based on a c-Src N-terminal peptide
- Can be used as an NMT substrate
- Classified under peptides
- Related to peptide and derivatives
- Falls under inhibitors and substrates
- Considered an enzyme substrate
Medchemexpress LLC Bibo3304 | 191868-14-1 | 100.0% | 643.66 | C31H36F3N7O5 | 25 MG
BIBO3304 is a potent, selective neuropeptide Y (NPY) Y1 receptor antagonist used as a research probe. It exhibits subnanomolar affinity at human and rat Y1 receptors (IC50 = 0.38 nM and 0.72 nM) and is supplied in solid and solution formats with high reported purity.
- High potency with subnanomolar IC50 values for human and rat Y1 receptors.
- High reported purity (99.96%).
- Available as solid and as a 10 mM DMSO solution for assay readiness.
- Molecular formula C31H36F3N7O5 and molecular weight 643.66 g/mol.
- Suitable for receptor pharmacology and in vitro pharmacodynamic studies.
Medchemexpress LLC DOTA-LM3 TFA | 99.3% | 1664.18 | 5 MG
DOTA-LM3 TFA is a somatostatin receptor (SSTR) antagonist. The LM3 component refers to p-Cl-Phe- cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr- NH2, which is also a somatostatin antagonist. This product is often isotopically labeled for in vivo tumor tracing, such as 177Lu-DOTA-LM3 TFA and 68Ga-DOTA-LM3 TFA. It can be used for the synthesis and research of Radionuclide-Drug Conjugates (RDCs).
- Acts as an antagonist for somatostatin receptors
- Commonly labeled with isotopes like 177Lu or 68Ga for in vivo tumor tracing
- 68Ga-DOTA-LM3 TFA exhibits favorable biodistribution
- Shows high tumor uptake and good tumor retention
- 68Ga-DOTA-LM3 TFA has few safety concerns
- Useful for research in DOTATOC-negative liver metastases, including pancreatic NET and extensive tumor thrombosis
- Can be utilized for the synthesis and research of Radionuclide-Drug Conjugates (RDCs)